Protein Structure Prediction

“Protein Structure Prediction” is an indispensable resource for anyone engaged in the rapidly evolving field of molecular biophysics. Whether you are a professional researcher, an undergraduate or graduate student, or simply an enthusiast, this book provides cuttingedge insights into the complex world of protein structure prediction. The ability to predict protein structures plays a crucial role in numerous applications, from drug discovery to understanding fundamental biological processes. This book offers a comprehensive, indepth exploration of the various aspects of protein structure prediction, bridging the gap between theory and practical applications.

Protein structure prediction-This chapter introduces the fundamental concepts and significance of protein structure prediction, setting the stage for the discussions to follow

Alpha helix-Focuses on the alpha helix, one of the most common structural motifs in proteins, and its role in the overall stability and function of proteins

Beta sheet-Explores the beta sheet structure, its formation, and how it contributes to the protein's tertiary structure and biological function

Protein secondary structure-Delves into the various secondary structural elements in proteins, explaining their influence on protein folding and stability

Protein tertiary structure-Discusses the threedimensional arrangement of secondary structure elements and the forces that stabilize this final structure

Membrane topology-This chapter covers the prediction of membrane protein structures and their complex interactions with lipid bilayers

Structural alignment-Introduces techniques used for aligning protein structures, essential for comparing and contrasting homologous proteins

Structural bioinformatics-A look at the computational tools and methods used in protein structure prediction and analysis

Protein structure-Provides an overview of the different levels of protein structure and how they relate to function

Protein design-Discusses the principles and methods behind designing proteins with specific functions, using computational techniques

Lattice protein-Explores the concept of lattice models in protein folding, helping understand how protein structures are formed

Threading (protein sequence)-Introduces threading techniques used to predict protein structures based on sequence similarities to known structures

Protein contact map-Focuses on the use of contact maps to predict protein folding and interactions

Turn (biochemistry)-Discusses the role of turns in protein structures, their formation, and significance in maintaining protein stability

Homology modeling-This chapter explores the process of creating threedimensional models of proteins based on sequence homology

Loop modeling-Focuses on the techniques for modeling loop regions in proteins, which are crucial for function and stability

De novo protein structure prediction-Provides an indepth look at approaches used to predict protein structures without relying on homologous templates

Protein domain-Discusses the modular nature of proteins and the importance of protein domains in their structure and function

Phyre-A case study of the Phyre server, a widely used tool for protein structure prediction, explaining its applications and methods

Protein superfamily-Introduces the concept of protein superfamilies and their significance in evolutionary biology and functional prediction

ITASSER-A detailed explanation of the ITASSER tool, a powerful method for protein structure prediction that integrates multiple techniques